Cotellic® (cobimetinib), 20 mg film-coated tablets, is a Prescription Medicine used in combination with Zelboraf® (vemurafenib) to treat a skin cancer called metastatic (spreading) melanoma that has a mutation (abnormal change) in the BRAF gene.
Ask your doctor if Cotellic is right for you.
Cotellic is an unfunded medicine. Ask your health professional about the cost of the medicine and other fees that may apply.
Use only as directed. If symptoms continue or you have side effects, see your healthcare professional. For more information about Cotellic:
- talk to your health professional; or
- visit govt.nz for Cotellic Consumer Medicine Information; or
- visit co.nz or call Roche on 0800 276 243.
Cotellic has risks and benefits.
Possible common side effects include: diarrhoea; nausea or vomiting; fever or chills; symptoms of dehydration (dry or sticky mouth, low or no urine output, urine looks dark yellow, no tears or sunken eyes); symptoms of anaemia (tiredness, headaches, being short of breath when exercising, dizziness and looking pale); sunburn or sun sensitivity; coughing, difficulty breathing or wheezing; skin problems (rashes, spots, itching, dry or scaly skin, hardened or thickened areas of the skin, painful red lumps or warts); swelling of hands or lower legs.
Things to be careful of: Be careful driving or operating machinery until you know how Cotellic affects you.
Do not use Cotellic if: you are allergic to cobimetinib or any ingredients in Cotellic tablets.
Tell your doctor if: you have any eye problems; you have any heart problems; you have any liver problems; you have any medical conditions that increase your risk of bleeding; you have any muscle problems; you have any problems with your kidneys; you are pregnant or breastfeeding, or plan to become pregnant or breastfeed; you are allergic to any other medicines, foods, dyes or preservatives; you are taking any other medicines, including any that you have bought from a pharmacy, supermarket or health food store.
Tell your doctor immediately or go to your nearest Accident and Emergency Centre if you notice any of the following: new or worsening problems with your eyes or vision (blurred vision, loss of vision or other vision changes, changes in colour, seeing a blurred outline around objects, eye pain, swelling or redness); a rash that covers a large area of your body, blisters, or peeling skin; symptoms of muscle damage (muscle aches, spasms or weakness, dark, reddish urine); symptoms of a serious bleeding problem (red or black stools that look like tar, blood in your urine or stools, unusual vaginal bleeding, headaches, dizziness, or feeling weak); symptoms of an allergic reaction (shortness of breath, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body, rash, itching or hives on the skin); symptoms of heart problems (persistent coughing or wheezing, shortness of breath, tiredness, increased heart rate, swelling of your ankles and feet).
Zelboraf® (vemurafenib), 240 mg film-coated tablets, is a Prescription Medicine used to treat a skin cancer called metastatic (spreading) melanoma that has a mutation (abnormal change) in the BRAF gene.
Do not use Zelboraf if: you are allergic to vemurafenib or any ingredients listed on the pack.
Before taking Zelboraf, tell your doctor if: you have a heart disorder or liver or kidney problems; you are pregnant or breast-feeding or plan to become pregnant or breastfeed; you have low levels of potassium, calcium or magnesium in your blood; you have been previously diagnosed with other types of cancer or received radiation treatment; you are allergic to any other medicines, foods, dyes or preservatives; you are taking any other medicines, including any that you have bought from a pharmacy, supermarket or health food store.
While you are taking Zelboraf: tell your doctor if you notice any skin changes such as a new wart, a skin sore or reddish bump or a sore that bleeds or does not heal. Avoid going out in the sun. Zelboraf can make your skin more sensitive to sunlight and you may burn more easily and get severe sunburn. Tell your doctor if you become pregnant while taking Zelboraf.
Tell your doctor immediately or go to your nearest Accident and Emergency Centre if you notice any of the following: difficulty breathing, chest tightness or wheezing; swelling of the face, lips or mouth; severe skin rash, itching, hives; severe blisters or bleeding of your lips, mouth, nose, or eyes; severe skin reaction starting with painful red areas, then large blisters and ends with peeling of layers of skin, accompanied by fever and chills, aching muscles and generally feeling unwell; fever associated with a mild to severe skin rash; severe light-headedness or dizziness, or feel your heart beating irregularly or fast; problems with your eyes or eyesight, such as blurred or altered vision, irritation, eye pain or redness; yellowing of the skin and eyes; light coloured bowel motions; dark coloured urine; severe upper stomach pain, often with nausea and vomiting (signs of inflammation of the pancreas). Possible common side-effects may also include: red skin rashes, itching, dry or scaly skin and hardened or thickened areas of the skin; painful red lumps or patches of skin that may appear darker or harder than usual; skin problems including warts; sunburn; increased sensitivity to light; loss of appetite and weight loss; headache; changes in the way things taste; drooping eyelid and sagging muscles on one side of the face caused by a paralysed nerve in the face (often reversible); tingling, burning or pain in your hands or feet; diarrhoea; constipation; hair loss; joint, muscle or back pain; unusual weakness; feeling sick or vomiting; feeling tired; fever; swelling (usually in the legs); cough; frequent infections such as fever, severe chills, sore throat or mouth ulcers; thickening or appearance of visible cords in the palm of one or both hands.
Zelboraf has risks and benefits. Ask your doctor if Zelboraf is right for you. Use strictly as directed. If symptoms continue or you have side effects, see your healthcare professional. For further information on Zelboraf, please talk to your health professional or visit www.medsafe.govt.nz for Zelboraf Consumer Medicine Information.
Zelboraf is not funded by PHARMAC. You will need to pay for this medicine. A prescription charge and normal doctor fees may apply.
