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Ovarian Cancer

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Avastin®

(bevacizumab)

Pronounced A-vas-tin

Avastin, also known as bevacizumab, is a targeted therapy for the treatment of a number of cancers including the treatment of ovarian cancer (including cancer of the fallopian tubes and peritoneal cancer). Avastin is given in combination with chemotherapy.

Avastin is not currently funded by PHARMAC for the treatment of ovarian cancer.  This means you will need to pay for the medicine yourself.

Ask your doctor if Avastin is right for you.

How Avastin works

Avastin is not a cure for ovarian cancer, but it may give you more time before your cancer grows and spreads further.

Avastin works by blocking an important growth factor called vascular endothelial growth factor or VEGF. This disrupts blood flow to the cancer, restricting the supply of nutrients that it needs to grow and spread.

Avastin is usually used with chemotherapy, which aims to kill the cancer cells. As Avastin and chemotherapy work in different ways, the two types of medicine complement each other when they are used to treat cancer.

To learn about Avastin please refer to the Avastin patient booklet by clicking here.

Ask your doctor if Avastin is right for you.

Clinical trial data

Studies have looked at how well Avastin works for women with ovarian cancer.

A large study of women with previously untreated advanced ovarian cancer, showed that when Avastin was added to chemotherapy, the average length of time patients lived without their tumours growing or spreading increased by just over 6 months, compared to patients who received chemotherapy alone.

Another large study in women with ovarian cancer that did not respond to chemotherapy (recurrent platinum-resistant ovarian cancer) showed that those given Avastin with chemotherapy remained free of their disease for longer, compared to those who received only chemotherapy.

Avastin has not been shown to improve overall survival (OS) in women with advanced ovarian cancer or recurrent platinum-resistant ovarian cancer.

Possible side effects of Avastin

Everyone reacts differently to Avastin, so it’s important to know what the side effects are. Some people may have serious side effects – however, most do not.

For more information on the potential side effects with Avastin treatment, download the Avastin Consumer Medicine Information here.

How to access Avastin

Avastin is not funded by PHARMAC for the treatment of advanced ovarian cancer. This means that you will need to pay for the medicine yourself.

Roche has created a Cost Share Programme which offers assistance with the cost of the medicine. The Avastin Cost Share Programme caps the cost of the medicine after either a specific number of doses or after a specific cost. Once a patient reaches the cap, Roche will provide ongoing Avastin at no cost. However, other costs (such as doctor fees and administration costs) will still apply.

Ask your doctor if Avastin is right for you, and how the Cost Share Programme could make it more affordable for you.

Ready to take the next step?

As every patient is different, it’s important to speak to your doctor to find out if Avastin is right for you.

Talking to your doctor about Avastin

Download discussion guide

For further information about private treatment providers click here.

You can also talk to your current doctor about referral to a private doctor or treatment centre.

Handy resources

Avastin patient booklet

This booklet is for designed for people receiving treatment with Avastin. It also contains important safety and side effect information. Please keep in mind that this booklet is not intended to replace medical advice from a doctor or other healthcare professionals.Download
Avastin Consumer Information
DOWNLOAD

Avastin® (bevacizumab), 100 mg/4mL and 400 mg/16 mL vials, is a Prescription Medicine used to treat metastatic (spreading) colorectal, kidney, breast, brain, lung, ovarian and cervical cancers.

Do not use Avastin if: you have had an allergic reaction to Avastin, any of its ingredients or other antibodies, or if you have been coughing or spitting up blood.

Tell your doctor if: you are pregnant or breast-feeding, or plan to become pregnant or breast-feed; you have any other health problems, especially the following: inflammation of the bowel or stomach ulcers, high blood pressure, a history of blood clots or stroke, bleeding problems, bleeding in the lungs or coughing or spitting up blood, low white blood cell counts, you have/ had a fistula, or have a history of diabetes; you have had major surgery in the last 28 days or a wound that has not healed properly; you have had a blocked lung artery (pulmonary embolism); you have heart disease; you have received anthracyclines (e.g. doxorubicin) for cancer, or radiotherapy to your chest; you are 65 years of age or older, or you are taking any other medicines.

Side Effects: Avastin may worsen some chemotherapy side effects when used in combination with chemotherapy agents, including hair loss, nail disorders, pain, redness and/or swelling of your hands and/or soles of your feet, and a feeling of numbness or tingling in the hands or feet.

Tell your doctor immediately or go to your nearest Accident and Emergency Centre if you notice any of the following: severe body pain and/or numbness (unable to sense pain or hot/cold temperatures on your body, arms, and/or legs. Any stomach pain or cramps; severe headache; severe diarrhoea, nausea and vomiting; loss of control of your bladder or bowels; passage of wind or bowel motions through the vagina; coughing or spitting up blood; pain, redness, swelling and warmth over a vein which may suggest blood clots; pain and/or swelling in the lower legs, feet or hands; severe bleeding or problems with your wounds healing after surgery; seizures; confusion; sleepiness/drowsiness or fainting; abscesses (pus-filled sores); severe infection with high fever, chills, headache, confusion and rapid breathing; feeling of numbness or tingling in feet or hands; dry mouth with thirst and/or darkened urine; increased heart rate; shortness of breath; symptoms of an allergic reaction which may include shortness of breath, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body, or rash, itching or hives on the skin.

Possible common side-effects may also include: high blood pressure (symptoms include, headache, dizziness, ringing in the ears, tiredness, blurred vision); body pain, tiredness/ weakness; diarrhoea, constipation or rectal bleeding; sore mouth or mouth ulcers; loss of appetite, being thirsty; shortness of breath; runny, blocked or bleeding nose; dry, scaling or inflamed skin, change in skin colour; taste changes or loss of taste; blurred vision (including increased production of tears, double visions, drooping eyelid(s), shimmering lights in your vision, sensitivity to light or temporary loss of sight; dizziness; trouble with your balance; headache; migraines; frequent infections with symptoms such as fever, chills or sore throat; changes in your voice or difficulty speaking or swallowing; loss of body weight;  abdominal, pelvic, rectal or back pain.

Avastin has risks and benefits. Ask your oncologist if Avastin is right for you. Use strictly as directed. If symptoms continue or you have side effects, see your healthcare professional. For further information on Avastin, please talk to your health professional or visit www.medsafe.govt.nz for Avastin Consumer Medicine Information.

Avastin is not funded by PHARMAC. You will need to pay the full cost of this medicine. A prescription charge and normal oncologist fees may apply.

Consumer panel dated 21 January 2021

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